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Gut-derived T cells might cause brain injury in NEC

Necrotizing enterocolitis (NEC) is an acute intestinal emergency in preterm infants, which is often later complicated by cognitive delay and neurodevelopmental disability. A new study performed in mice suggests that CD4+ T cells can travel from the NEC-inflamed gut to the brain and cause IFNγ-mediated brain injury.

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Fig. 1: Proposed mechanism for white matter injury in preterm infants with NEC.


  1. Coggins, S. A., Wynn, J. L. & Weitkamp, J.-H. Infectious causes of necrotizing enterocolitis. Clin. Perinatol. 42, 133–54 (2015).

    Article  Google Scholar 

  2. Rees, C. M., Pierro, A. & Eaton, S. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Arch. Dis. Child Fetal. Neonatal Ed. 92, F193–198 (2007).

    Article  Google Scholar 

  3. Lodha, A., Asztalos, E. & Moore, A. M. Cytokine levels in neonatal necrotizing enterocolitis and long-term growth and neurodevelopment. Acta Paediatr. 99, 338–343 (2010).

    CAS  Article  Google Scholar 

  4. Zhou, Q. et al. Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain. Sci. Transl. Med. 13, eaay6621 (2021).

    CAS  Article  Google Scholar 

  5. Weitkamp, J.-H. et al. Necrotizing enterocolitis is characterized by disrupted immune regulation and diminished mucosal regulatory (FOXP3+) / effector (CD4+, CD8+) T cell ratios. Gut 62, 73–82 (2013).

    CAS  Article  Google Scholar 

  6. Nazmi, A. et al. Lymphocytes contribute to the pathophysiology of neonatal brain injury. Front. Neurol. 9, 159 (2018).

    Article  Google Scholar 

  7. Lavoie, P. M. et al. Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis. J. Infect. Dis. 202, 1754–63 (2010).

    CAS  Article  Google Scholar 

  8. Duc, D. et al. Disrupting myelin-specific Th17 cell gut homing confers protection in an adoptive transfer experimental autoimmune encephalomyelitis. Cell Reports 2, 378–390 (2019).

    Article  Google Scholar 

  9. Matta, P. et al. In utero exposure to histological chorioamnionitis primes the exo-metabolomic profile of preterm CD4+ T lymphocytes. J. Immunol. 199, 3074–3085 (2017).

    CAS  Article  Google Scholar 

  10. Frost, B. L., Modi, B. P., Jaksic, T. & Caplan, M. S. New medical and surgical insights into neonatal necrotizing enterocolitis: a review. JAMA Pediatr. 171, 83–88 (2017).

    Article  Google Scholar 

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Correspondence to Jörn-Hendrik Weitkamp.

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J.-H.W. serves as a consultant to Roche Diagnostics Corporation.

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Weitkamp, JH. Gut-derived T cells might cause brain injury in NEC. Nat Rev Gastroenterol Hepatol 18, 291–292 (2021).

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