Genomic alterations are well-described in Barrett oesophagus and its sequela, oesophageal adenocarcinoma, but epigenomic events have not been so widely investigated. In a new study, Jammula et al. analysed the DNA methylation profiles of Barrett oesophagus, oesophageal adenocarcinoma and control tissues. Four molecular subtypes were identified, revealing four distinct epigenomic classes and potential therapeutic targets.
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S.J.M. owns partial equity and patent rights in Capsulomics, Inc. This interest is not directly relevant to the topic of this manuscript.
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Meltzer, S.J. Molecular epigenomic subtypes of Barrett neoplasia. Nat Rev Gastroenterol Hepatol 17, 261–262 (2020). https://doi.org/10.1038/s41575-020-0292-x