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Functional lineage tracing to study the clonal evolution of therapy resistance

Nature Reviews Cancer volume 22, page 321 (2022)Cite this article

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Despite many significant advances in cancer therapies, resistance still remains a critical problem preventing durable responses and complete cures. While it is important to dissect the molecular mechanisms of therapy resistance, understanding how resistance evolves can unveil additional therapeutic opportunities.

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Original article

  • Umkehrer, C. et al. Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters. Nat. Biotechnol. 39, 174–178 (2021)

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  1. Cancer Cell Signaling, Boehringer-Ingelheim RCV GmbH & Co KG, Vienna, Austria

    Christian Umkehrer

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  1. Christian Umkehrer
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Correspondence to Christian Umkehrer.

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Umkehrer, C. Functional lineage tracing to study the clonal evolution of therapy resistance. Nat Rev Cancer 22, 321 (2022). https://doi.org/10.1038/s41568-022-00479-w

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  • DOI: https://doi.org/10.1038/s41568-022-00479-w

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