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When specialized clones go global

Multi-drug resistant Mycobacterium abscessus clones from individuals who smoke have infiltrated the narrow niche of patients with cystic fibrosis, which has resulted in surprising specialization and subsequent worldwide dissemination.

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Fig. 1: Large-scale adaptive jumps versus local fine-tuning of human pathogens.


  1. Ruis, C. et al. Nat. Microbiol. (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Sapriel, G. et al. BMC Genomics 17, 118 (2016).

    Article  Google Scholar 

  3. Bryant, J. M. et al. Science 372, eabb8699 (2021).

    CAS  Article  Google Scholar 

  4. Rasmussen, S. et al. Cell 163, 571–582 (2015).

    CAS  Article  Google Scholar 

  5. Linz, B. et al. Nature 445, 915–918 (2007).

    Article  Google Scholar 

  6. Comas, I. et al. Nat. Genet. 45, 1176–1182 (2013).

    CAS  Article  Google Scholar 

  7. Wong, V. K. et al. Nat. Genet. 47, 632–639 (2015).

    CAS  Article  Google Scholar 

  8. Wirth, T. Nat. Genet. 47, 565–567 (2015).

    CAS  Article  Google Scholar 

  9. Holt, K. E. et al. Nat. Genet. 44, 1056–1059 (2012).

    CAS  Article  Google Scholar 

  10. Wirth, T. et al. Nat. Microbiol. 5, 735–745 (2020).

    CAS  Article  Google Scholar 

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Correspondence to Thierry Wirth.

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Wirth, T. When specialized clones go global. Nat Microbiol 6, 1215–1216 (2021).

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