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The double life of autophagy proteins

It is now clear that key autophagy proteins possess alternative functions, distinct from their conventional roles in autophagy. Adding to this emerging field, a new study shows how ATG16L1 acts to promote plasma membrane repair following damage by pore-forming bacteria.

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Fig. 1: Multiple functions of the ATG16L1 complex.

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Correspondence to Oliver Florey.

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Florey, O. The double life of autophagy proteins. Nat Microbiol 3, 1334–1335 (2018). https://doi.org/10.1038/s41564-018-0310-8

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