Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
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Hardeman, E.C., Gunning, P.W. Life and death agendas of actin filaments. Nat. Mater. 19, 135–136 (2020). https://doi.org/10.1038/s41563-019-0583-1
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation
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