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RIGIDITY SENSING

Life and death agendas of actin filaments

Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.

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Fig. 1: Actin filaments with opposing life and death agendas.

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Correspondence to Edna C. Hardeman.

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E.C.H. and P.W.G. are directors and shareholders in TroBio Therapeutics Pty Ltd, a company commercializing the use of anti-tropomyosin drugs.

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Hardeman, E.C., Gunning, P.W. Life and death agendas of actin filaments. Nat. Mater. 19, 135–136 (2020). https://doi.org/10.1038/s41563-019-0583-1

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