Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.
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Data from the UKB and 23andMe are available on application to each site (UKB, https://www.ukbiobank.ac.uk; 23andMe, https://research.23andme.com/dataset-access/). Summary statistics of Okbay and colleagues7 are publicly available at the Social Science Genetic Association Consortium (SSGAC, https://www.thessgac.org/). The full summary statistics of the KBA GWAS are available at the NHGRI-EBI GWAS Catalog (https://www.ebi.ac.uk/gwas/downloads).
Previously developed pipelines were used to produce the results for the current study. No custom code was developed. Please see the Supplementary Information for details on the software URLs and data used.
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KBA genotype data were provided by the Collaborative Genome Program for Fostering New Post-Genome Industry (3000–3031b), and UKB data were obtained under application no. 33002. This study was supported by the National Research Foundation of Korea Grant funded by the Ministry of Science and Information and Communication Technologies, South Korea (grant no. NRF‐2018R1C1B6001708 and NRF-2021R1A2C4001779 to W.M. and NRF-2019R1A2C4070496 and NRF-2022R1A2C2009998 to H.H.W.) and by an intramural grant from the Korea National Institute of Health (2019-NG-053-01). This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant nos. HI19C1132 and HI19C1328000020 to H.H.W. and S.K., respectively). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Woong-Yang Park is employed by a commercial company, GENINUS. GENINUS has no particular conflict of interest with the current work. The remaining authors declare no competing interests.
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Kim, S., Kim, K., Hwang, M.Y. et al. Shared genetic architectures of subjective well-being in East Asian and European ancestry populations. Nat Hum Behav (2022). https://doi.org/10.1038/s41562-022-01343-5