Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

PREBIOTIC CHEMISTRY

Making nucleic acid monomers

Amino-containing four-carbon threose nucleic acids (TNAs) have long been considered to be prebiotically irrelevant due to their difficult formation. Now, a prebiotically plausible route to 3′-amino-TNA nucleoside triphosphate has been developed, raising the possibility of 3′-amino-TNA as a non-canonical nucleic acid during the origin of life.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: The streamlined scheme of 3′-amino-threose nucleic acid triphosphate synthesis under prebiotically plausible conditions.

References

  1. Gilbert, W. Nature 319, 618 (1986).

    Article  Google Scholar 

  2. Kim, S. C., O’Flaherty, D. K., Giurgiu, C., Zhou, L. & Szostak, J. W. J. Am. Chem. Soc. 143, 3267–3279 (2021).

    CAS  Article  Google Scholar 

  3. Kim, S. C. et al. J. Am. Chem. Soc. 142, 2317–2326 (2020).

    CAS  Article  Google Scholar 

  4. Eschenmoser, A. Science 284, 2118–2124 (1999).

    CAS  Article  Google Scholar 

  5. Schöning, K.-U. et al. Science 290, 1347–1351 (2000).

    Article  Google Scholar 

  6. Ferencic, M. et al. Chem. Biodivers. 1, 939–979 (2004).

    CAS  Article  Google Scholar 

  7. Schöning, K. et al. Helv. Chim. Acta. 85, 4111–4153 (2002).

    Article  Google Scholar 

  8. Colville, B. W. F. & Powner, M. W. Angew. Chem. Int. Ed. 60, 10526–10530 (2021).

    CAS  Article  Google Scholar 

  9. Eschenmoser, A. OLEB 34, 277–306 (2004).

    CAS  Google Scholar 

  10. Whitaker, D. & Powner, M. W. Nat. Chem. https://doi.org/10.1038/s41557-022-00982-5 (2022).

    Article  PubMed  Google Scholar 

  11. Blain, J. C., Ricardo, A. & Szostak, J. W. J. Am. Chem. Soc. 136, 2033–2039 (2014).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yajun Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Liu, Y., Wang, Y. Making nucleic acid monomers. Nat. Chem. 14, 725–727 (2022). https://doi.org/10.1038/s41557-022-00985-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41557-022-00985-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing