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MACROCYCLIC METATHESIS

Trisubstituted triumph

Trisubstituted macrocyclic alkenes are prominent moieties in natural products, and although ring-closing metathesis reactions can be used to access such targets, the yields are typically suboptimal and the stereochemical outcome is unpredictable. Now, a methodology has been developed that tackles both of these challenges.

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Fig. 1: Macrocyclic ring-closing metathesis for the synthesis of E- and Z-trisubstituted macrocyclic alkenes.

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Correspondence to Damian W. Young.

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Young, D.W., Chamakuri, S. Trisubstituted triumph. Nat. Chem. 14, 595–597 (2022). https://doi.org/10.1038/s41557-022-00959-4

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