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SYNTHETIC METHODOLOGY

Tungsten’s tandem transformation

Being able to run two reactions concurrently enables synthetic methods to be streamlined, but simultaneously controlling the selectivity of both reactions is an enormous challenge. Now, a directing group is used to reinvent a classic tandem reaction, activating specific sp3 C–H bonds with pinpoint accuracy.

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Fig. 1: Overview of isomerization/carbonylation tandem catalysis.

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Correspondence to Graham E. Dobereiner.

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Jenny, S.E., Dobereiner, G.E. Tungsten’s tandem transformation. Nat. Chem. 14, 594–595 (2022). https://doi.org/10.1038/s41557-022-00953-w

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