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ELECTROCHEMISTRY

Bringing amines back into aziridination

Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.

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Fig. 1: Development of a new strategy for aziridination synthesis.

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Correspondence to Louis-Charles Campeau.

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Piou, T., Campeau, LC. Bringing amines back into aziridination. Nat. Chem. 13, 1027–1028 (2021). https://doi.org/10.1038/s41557-021-00819-7

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