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SYNTHETIC METHODOLOGY

Building bridges

Methods for the synthesis of bicyclo[1.1.1]pentanes (BCPs) typically rely on the release of strain energy, but these routes cannot easily introduce substituents on the BCP bridges. Now, an intramolecular coupling gives access to multi-substituted BCPs, through the synthesis of bridge-substituted bicycloalkyl boronic esters.

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Fig. 1: Methods to access bridgehead-substituted BCPs.

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Correspondence to Cara E. Brocklehurst.

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Brocklehurst, C.E., Anderson, E.A. Building bridges. Nat. Chem. 13, 928–930 (2021). https://doi.org/10.1038/s41557-021-00784-1

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