Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

INTERLOCKED MOLECULES

Tying peptide ropes

Although the natural lasso peptide microcin J25 remains an elusive target for total chemical synthesis itself, this topologically non-trivial building block has now been used to construct a range of interlocked molecular architectures including rotaxanes, catenanes and daisy chains.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: A lasso peptide and its conversion into other structures.

References

  1. 1.

    Salomón, R. A. & Farías, R. N. J. Bacteriol. 174, 7428–7435 (1992).

    Article  Google Scholar 

  2. 2.

    Bayro, M. J. et al. J. Am. Chem. Soc. 125, 12382–12383 (2003).

    CAS  Article  Google Scholar 

  3. 3.

    Rosengren, K. J. et al. J. Am. Chem. Soc. 125, 12464–12474 (2003).

    CAS  Article  Google Scholar 

  4. 4.

    Wilson, K.-A. et al. J. Am. Chem. Soc. 125, 12475–12483 (2003).

    CAS  Article  Google Scholar 

  5. 5.

    Hegemann, J. D., Zimmerman, M., Xie, X. & Marahiel, M. A. Acc. Chem. Res. 48, 1909–1919 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Martin-Gómez, H. & Tulla-Puche, J. Org. Biomol. Chem. 16, 5065–5080 (2018).

    Article  Google Scholar 

  7. 7.

    Rowe, S. M. & Spring, D. R. Chem. Soc. Rev. 50, 4245–4258 (2021).

    CAS  Article  Google Scholar 

  8. 8.

    Chen, M., Wang, S. & Yu, X. Chem. Commun. 55, 3323–3326 (2019).

    CAS  Article  Google Scholar 

  9. 9.

    Piscotta, F. J., Tharp, J. M., Liu, W. R. & Link, A. J. Chem. Commun. 51, 409–412 (2015).

    CAS  Article  Google Scholar 

  10. 10.

    Schröder, H. V., Zhang, Y. & Link, A. J. Nat. Chem. https://doi.org/10.1038/s41557-021-00770-7 (2021).

    Article  PubMed  Google Scholar 

  11. 11.

    Heinis, C., Rutherford, T., Freund, S. & Winter, G. Nat. Chem. Biol. 5, 502–507 (2009).

    CAS  Article  Google Scholar 

  12. 12.

    Si, Y., Kretsch, A. M., Daigh, L. M., Burk, M. J. & Mitchell, D. A. J. Am. Chem. Soc. 143, 5917–5927 (2021).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jan H. van Maarseveen.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

van Maarseveen, J.H. Tying peptide ropes. Nat. Chem. 13, 822–823 (2021). https://doi.org/10.1038/s41557-021-00771-6

Download citation

Search

Quick links