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SYNTHETIC METHODOLOGY

Mastering mono-bond metathesis

Carbon–carbon single bonds are generally among the least reactive chemical bonds. While olefin metathesis reactions are well established, direct metathesis of C–C single bonds is rare. Now, a C–C single bond metathesis reaction has been developed, forming cross-biaryl products from unstrained homo-biaryl compounds.

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Fig. 1: The development of intermolecular biaryl C–C bond metathesis.

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Correspondence to Daniel J. Weix.

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Gilbert, M.M., Weix, D.J. Mastering mono-bond metathesis. Nat. Chem. 13, 818–820 (2021). https://doi.org/10.1038/s41557-021-00754-7

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