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automated synthesis

Solid potential

Small-molecule drug discovery and development is limited by the ability of chemists to readily synthesize and purify new compounds with suitable chemical diversity. Now, a new twist on solid-phase chemical synthesis has enabled rapid and simplified synthesis of pharmaceutically relevant small molecules.

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Fig. 1: Solid-supported synthesis of prexasertib.


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Correspondence to Kevin P. Cole.

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Kerr, M.S., Cole, K.P. Solid potential. Nat. Chem. 13, 399–401 (2021).

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