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MECHANOBIOLOGY

Softening redox homeostasis in cancer cells

Extracellular matrix (ECM) rigidity increases during tumour progression. In a recent study, Romani et al. delineated a connection between ECM stiffness and the redox response of disseminated tumour cells. Their results suggest that soft ECM promotes DRP1-mediated mitochondrial fission and an NRF2-dependent antioxidant response.

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Fig. 1: Mechanosignaling through changes in cell adhesion and matrix stiffness regulates the dynamin-related protein 1 (DRP1)–nuclear factor erythroid 2-related factor 2 (NRF2) axis in disseminated breast cancer cells.

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Correspondence to Iok In Christine Chio.

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Powers, J.A., Chio, I.I.C. Softening redox homeostasis in cancer cells. Nat Cell Biol 24, 133–134 (2022). https://doi.org/10.1038/s41556-022-00845-8

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