Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


An RNA helicase swirls in lymphangiogenesis

How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Discovery, mechanism and implications for the new findings on the role of Ddx21 in lymphangiogenesis.


  1. 1.

    Lohela, M. et al. Curr. Opin. Cell Biol. 21, 154–165 (2009).

    CAS  Article  Google Scholar 

  2. 2.

    Koltowska, K. et al. Nat. Cell Biol. (2021).

    Article  Google Scholar 

  3. 3.

    Hogan, B. M. & Schulte-Merker, S. Dev. Cell 42, 567–583 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Bianchi, R. et al. Arterioscler. Thromb. Vasc. Biol. 37, 108–117 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Mendola, A. et al. Mol. Syndromol. 4, 257–266 (2013).

    CAS  Article  Google Scholar 

  6. 6.

    Calo, E. et al. Nature 518, 249–253 (2015).

    CAS  Article  Google Scholar 

  7. 7.

    Song, C. et al. Genes Dev. 31, 1370–1381 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Lee, H.-W., Yu, P. & Simons, M. F1000Res. 7, 1114 (2018).

    Article  Google Scholar 

  9. 9.

    Pontes-Quero, S. et al. Nat. Commun. 10, 2016 (2019).

    Article  Google Scholar 

  10. 10.

    Jerafi-Vider, A. et al. Cell Rep. 35, 109255 (2021).

    CAS  Article  Google Scholar 

  11. 11.

    Kang, J. et al. Sig. Transduct. Target. Ther. 6, 323 (2021).

    CAS  Article  Google Scholar 

  12. 12.

    Macias, E. et al. Cancer Cell 18, 231–243 (2010).

    CAS  Article  Google Scholar 

  13. 13.

    Van Riggelen, J., Yetil, A. & Felsher, D. W. Nat. Rev. Cancer 10, 301–309 (2010).

    Article  Google Scholar 

  14. 14.

    Kampen, K. R. et al. Nucleic Acids Res. 48, 1013–1028 (2020).

    CAS  Article  Google Scholar 

  15. 15.

    Calo, E. et al. Nature 554, 112–117 (2018).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Rui Benedito.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mühleder, S., Benedito, R. An RNA helicase swirls in lymphangiogenesis. Nat Cell Biol 23, 1109–1110 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing