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H3.3 safeguards haematopoietic ERV-quilibrium

Cell fate determination by H3.3 deposition in haematopoietic stem and progenitor cells is largely unexplored. Two studies jointly support the idea that H3.3 maintains haematopoiesis balance and prevents endogenous retroviral element (ERV) activation through chromatin marks and transcriptome alterations.

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Fig. 1: H3.3 and its chaperone Daxx are involved in maintaining a balance in haematopoiesis.


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Correspondence to Yuin-Han Loh.

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Cipta, N.O., Chen, Y. & Loh, YH. H3.3 safeguards haematopoietic ERV-quilibrium. Nat Cell Biol 24, 7–9 (2022).

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