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SIGNALLING

Exosomes deliver ROS for regeneration

Inflammation and reactive oxygen species (ROS) production after central nervous system injury are thought to enhance tissue damage and hamper neuronal regeneration. Evidence now suggests that NADPH2 oxidase delivery from macrophages to injured neurons through extracellular vesicles, promotes ROS signalling and axon recovery.

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Fig. 1: ROS signalling in sensory nerve regeneration.

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Correspondence to Eva-Maria Krämer-Albers.

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Krämer-Albers, EM. Exosomes deliver ROS for regeneration. Nat Cell Biol 20, 225–226 (2018). https://doi.org/10.1038/s41556-018-0048-9

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