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Exosomes deliver ROS for regeneration

Inflammation and reactive oxygen species (ROS) production after central nervous system injury are thought to enhance tissue damage and hamper neuronal regeneration. Evidence now suggests that NADPH2 oxidase delivery from macrophages to injured neurons through extracellular vesicles, promotes ROS signalling and axon recovery.

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Fig. 1: ROS signalling in sensory nerve regeneration.


  1. 1.

    Abe, N. & Cavalli, V. Curr. Opin. Neurobiol. 18, 276–283 (2008).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Jiang, F., Zhang, Y. & Dusting, G. J. Pharmacol. Rev. 63, 218–242 (2011).

    CAS  Article  Google Scholar 

  3. 3.

    Hervera. et al. Nat. Cell Biol. (2018).

  4. 4.

    Richardson, P. M. & Issa, V. M. Nature 309, 791–793 (1984).

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Neumann, S. & Woolf, C. J. Neuron 23, 83–91 (1999).

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Lambeth, J. D. Nat. Rev. Immunol. 4, 181–189 (2004).

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Holmstrom, K. M. & Finkel, T. Nat. Rev. Mol. Cell Biol. 15, 411–421 (2014).

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Imai, T. et al. Cell 91, 521–530 (1997).

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Colombo, M., Raposo, G. & Thery, C. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014).

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Yanez-Mo, M. et al. J. Extracell. Vesicles 4, 27066 (2015).

    Article  PubMed  Google Scholar 

  11. 11.

    Krämer-Albers, E. M. & Hill, A. F. Curr. Opin. Neurobiol. 39, 101–107 (2016).

    Article  PubMed  Google Scholar 

  12. 12.

    Budnik, V., Ruiz-Canada, C. & Wendler, F. Nat. Rev. Neurosci. 17, 160–172 (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Eva-Maria Krämer-Albers.

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Krämer-Albers, EM. Exosomes deliver ROS for regeneration. Nat Cell Biol 20, 225–226 (2018).

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