Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

BRAIN–COMPUTER INTERFACES

From unstable input to robust output

In the presence of recording instabilities, the performance of brain–computer interfaces can be robustly maintained by exploiting ‘hidden’ structures underlying neural activity.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Patterns in the underlying activity of simultaneously recorded neurons can be leveraged to improve the robustness of decoders for BCIs.

References

  1. Pandarinath, C. et al. eLife 6, 18554 (2017).

    Article  Google Scholar 

  2. Collinger, J. L. et al. Lancet 381, 557–564 (2013).

    Article  Google Scholar 

  3. Anumanchipalli, G. K., Chartier, J. & Chang, E. F. Nature 568, 493–498 (2019).

    CAS  Article  Google Scholar 

  4. Ajiboye, A. B. et al. Lancet 389, 1821–1830 (2017).

    Article  Google Scholar 

  5. Sussillo, D., Stavisky, S. D., Kao, J. C., Ryu, S. I. & Shenoy, K. V. Nat. Commun. 7, 13749 (2016).

    CAS  Article  Google Scholar 

  6. Downey, J. E., Schwed, N., Chase, S. M., Schwartz, A. B. & Collinger, J. L. J. Neural Eng. 15, 046016 (2018).

    Article  Google Scholar 

  7. Degenhart, A. D. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-0542-9 (2020).

  8. Gallego, J. A., Perich, M. G., Miller, L. E. & Solla, S. A. Neuron 94, 978–984 (2017).

    CAS  Article  Google Scholar 

  9. Sadtler, P. T. et al. Nature 512, 423–426 (2014).

    CAS  Article  Google Scholar 

  10. Kao, J. C., Ryu, S. I. & Shenoy, K. V. Sci. Rep. 7, 7395 (2017).

    Article  Google Scholar 

  11. Dyer, E. L. et al. Nat. Biomed. Eng. 1, 967–976 (2017).

    Article  Google Scholar 

  12. Pandarinath, C. et al. Nat. Meth. 15, 805–815 (2018).

    CAS  Article  Google Scholar 

  13. Farshchian, A. et al. In International Conference on Learning Representations (OpenReview.net, 2019).

  14. Gallego, J. A., Perich, M. G., Chowdhury, R. H., Solla, S. A. & Miller, L. E. Nat. Neurosci. 23, 260–270 (2020).

    CAS  Article  Google Scholar 

  15. Jarosiewicz, B. et al. Sci. Transl. Med. 7, 313ra179 (2015).

    Article  Google Scholar 

  16. Oby, E. R. et al. Proc. Natl Acad. Sci. USA 116, 15210–15215 (2019).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chethan Pandarinath.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wimalasena, L.N., Miller, L.E. & Pandarinath, C. From unstable input to robust output. Nat Biomed Eng 4, 665–667 (2020). https://doi.org/10.1038/s41551-020-0587-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-020-0587-9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing