Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CANCER MECHANOBIOLOGY

Epigenetic regulation of mechanotransduction

The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Mechanisms of mechanotransduction and the role of the epigenome.

References

  1. Piersma, B., Hayward, M. K. & Weaver, V. M. Biochim. Biophys. Acta Rev. Cancer 1873, 188356 (2020).

    CAS  Article  Google Scholar 

  2. Nemec, S. & Kilian, K. A. Nat. Rev. Mater. https://doi.org/10.1038/s41578-020-00238-z (2020).

  3. Flavahan, W. A., Gaskell, E. & Bernstein, B. E. Science 357, eaal2380 (2017).

    Article  Google Scholar 

  4. Jang, M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-00657-x (2020).

  5. Branco da Cunha, C. et al. Biomaterials 35, 8927–8936 (2014).

    CAS  Article  Google Scholar 

  6. Killaars, A. R. et al. Adv. Sci. 6, 1801483 (2019).

    Article  Google Scholar 

  7. Jain, N., Iyer, K. V., Kumar, A. & Shivashankar, G. V. Proc. Natl Acad. Sci. USA 110, 11349–11354 (2013).

    CAS  Article  Google Scholar 

  8. Stowers, R. S. et al. Nat. Biomed. Eng. 3, 1009–1019 (2019).

    Article  Google Scholar 

  9. Bintu, L. et al. Science 351, 720–724 (2016).

    CAS  Article  Google Scholar 

  10. Balestrini, J. L., Chaudhry, S., Sarrazy, V., Koehler, A. & Hinz, B. Integr. Biol. 4, 410–421 (2012).

    CAS  Article  Google Scholar 

  11. Yang, C., Tibbitt, M. W., Basta, L. & Anseth, K. S. Nat. Mater. 13, 645–652 (2014).

    CAS  Article  Google Scholar 

  12. Elosegui-Artola, A. et al. Nat. Cell Biol. 18, 540–548 (2016).

    CAS  Article  Google Scholar 

  13. Shiu, J.-Y., Aires, L., Lin, Z. & Vogel, V. Nat. Cell Biol. 20, 262–271 (2018).

    CAS  Article  Google Scholar 

  14. Lee, J. Y. et al. Nat. Commun. 10, 1848 (2019).

    Article  Google Scholar 

  15. Panciera, T. et al. Nat. Mater. 19, 797–806 (2020).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Ryan Stowers or Ovijit Chaudhuri.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Stowers, R., Chaudhuri, O. Epigenetic regulation of mechanotransduction. Nat Biomed Eng 5, 8–10 (2021). https://doi.org/10.1038/s41551-020-00678-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-020-00678-6

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing