Single- and multifrequency bioelectrical impedance analysis (BIA) has gained popularity as a tool to assess body composition and health status of children and adolescents, but many questions and misconceptions remain. This review addresses pressing issues researchers and health care providers may encounter when using BIA in the young population. The importance of choosing population-specific and device-specific equations to estimate body composition as well as the use of BIA in longitudinal analyses are discussed. When specific equations are not available, raw bioimpedance values (i.e., resistance, reactance, and impedance) can be used to compute bioimpedance parameters, such as phase angle, impedance ratio, and bioelectrical impedance vector analysis. As interpreting these parameters is challenging, suggestions are provided on the use of reference data, cut-off points, and adjustment factors. Furthermore, unsolved technical and analytical issues are listed. Based on existing issues and potential for future development, a greater interaction between industry and academic researchers to improve the validity of BIA measurements among children and adolescents across their developmental stages is encouraged.
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We thank Bianca Caroline Orsso for her assistance with the illustrations. A portion of this work has been funded by the generous support of the Stollery Children’s Hospital Foundation through the Women and Children’s Health Research Institute (RES0040520).
C.E.O declares no competing financial interests. MCG reports receiving honoraria from Abbott Nutrition and Nestle Health Science, outside the scope of the submitted work. MJM is employed by Seca gmbh & co. kg. AMH has received grant funding from Rhythm pharmaceuticals and Levo therapeutics outside the scope of the submitted work. CMP reports receiving honoraria and/or paid consultancy from Abbott Nutrition, Nutricia, Nestle Health Science, Fresenius Kabi, Pfizer, and Helsinn outside the scope of the submitted work.
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Orsso, C.E., Gonzalez, M.C., Maisch, M.J. et al. Using bioelectrical impedance analysis in children and adolescents: Pressing issues. Eur J Clin Nutr (2021). https://doi.org/10.1038/s41430-021-01018-w