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A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau

Cell Research volume 31, pages 1032–1035 (2021)Cite this article

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Fig. 1: Substitution of a parallel amino acid of RETSAT among QTP mammals endows mice with convergent phenotypes and enhanced hypoxia tolerance.

Data availability

The raw sequence data reported in this study have been deposited in the Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences (accession numbers CRA000080, CRA000079). They are publicly accessible at https://bigd.big.ac.cn/gsa. The assemblies for the plateau zokor and plateau pika have been deposited in the BIG Genome Warehouse (GWH) under project numbers GWHABJY00000000 and GWHABJX00000000. The RETSAT protein sequence alignment across 137 mammals has been uploaded to the Dryad Digital Repository (doi:10.5061/dryad.ttdz08kxg).

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Acknowledgements

We thank Zhengting Zou for modifying the computational program of convCalScript and Zhong-Ru Gu for his advice in genome assembly. This work was supported jointly and equally by the Second Tibetan Plateau Scientific Expedition and Research Program (2019QZKK0501) and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13020400). This work was also supported by the National Natural Science Foundation of China (U1902216, 81772996, 81672764, 31621062, 31871270, 31922010, 31871277, 3190013), Science and Technology Department of Qinghai Province (Sanjiangyuan National Park Animal Genome Program), and Yunnan Applied Basic Research Projects (2016FA009, 2019FJ009). C.Y., S.P. and Z.L. were also supported by the Youth Innovation Promotion Association, CAS, and the Youth Talent Support Program of Yunnan Province (2019FI008).

Author information

Author notes

  1. These authors contributed equally: Dongming Xu, Cuiping Yang, Qiushuo Shen, Shengkai Pan, Zhen Liu, Tongzuo Zhang

Affiliations

  1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China

    Dongming Xu, Zhen Liu, Xin Zhou, Menglong Lei, Peng Chen, Hui Yang, Tao Zhang, Yuanting Guo & Peng Shi

  2. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China

    Cuiping Yang, Qiushuo Shen & Yongbin Chen

  3. Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

    Shengkai Pan & Xiangjiang Zhan

  4. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan, China

    Zhen Liu, Xiangjiang Zhan, Yongbin Chen & Peng Shi

  5. Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, China

    Tongzuo Zhang

  6. Qinghai Provincial Key Laboratory of Animal Ecological Genomics, Xining, Qinghai, China

    Tongzuo Zhang

  7. University of the Chinese Academy of Sciences, Beijing, China

    Peng Chen, Tao Zhang & Yuanting Guo

  8. School of Future Technology, University of Chinese Academy of Sciences, Beijing, China

    Peng Shi

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  1. Dongming Xu
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Contributions

P.S., Y.C., and X.-J.Z. designed and supervised the project. P.S. coordinated the project. X.-J.Z. led the genome assembly group. Y.C. led the functional experiment group. P.S. led the evolutionary genome analysis group. T.-Z.Z. collected samples. D.X., S.P., and X.-J.Z. performed genome assembly and annotation. D.X., Z.L., H.Y., T.Z., Y.G., P.C., and P.S. analyzed genomic data. C.Y., Q.S., X.Z., M.L., and Y.C. performed functional experiments. D.X., Z.L., Y.C., C.Y., X.-J.Z., and P.S. wrote the manuscript.

Corresponding authors

Correspondence to Xiangjiang Zhan, Yongbin Chen or Peng Shi.

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The authors declare no competing interests.

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Xu, D., Yang, C., Shen, Q. et al. A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau. Cell Res 31, 1032–1035 (2021). https://doi.org/10.1038/s41422-021-00517-6

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  • DOI: https://doi.org/10.1038/s41422-021-00517-6

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