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C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy

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Fig. 1: Description of alloHSCT subjects and documentation of complement deposition in cutaneous and bone marrow microvasculature in those with and without TMA.

Data availability

Data used and/or analyzed during this study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank Daniel Greenberg, Sharon Barouk-Fox, Paula Bertram, Beatriz Lorenzo, Levi Y. Elhadad, and Yuzhou Zhang in the laboratory of Dr. Richard Smith of the University of Iowa for expert technical work. This work was supported by funds from: Omeros (JL), Jazz Pharmaceuticals (JL), and the NIH (RO1 HL148123 and HL123605 (JA), and R01 GM099111 (JPA.) and U54 HL112303 (JPA and EDOR)).

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Contributions

JL conceived the study and wrote the paper. SE, KVB, AC, EDOR, EO, and JPA edited the manuscript and provided important insights. JPA and EDOR performed the genetic analyses. CM performed the skin biopsy analyses. AC performed the bone marrow analyses. SE, DC, SG, and JA performed select studies, provided insights and help edit the manuscript. SE, DC, and SG did the statistical analyses. WR, JG, and JC coordinated patient studies. LBR, UG, SM, and TS treated these patients and obtained the blood and bone marrow aspirate samples.

Corresponding author

Correspondence to Jeffrey Laurence.

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Competing interests

JL has received a research grant and JL and UG have received speaker fees from Alexion. JL and SM have current research grants from Omeros, Inc., and JL from Jazz Pharmaceuticals. These entities did not have input in the study design, analysis, manuscript preparation, or decision to submit for publication. The remaining authors declare no competing financial interests.

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Elhadad, S., Chadburn, A., Magro, C. et al. C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy. Bone Marrow Transplant (2022). https://doi.org/10.1038/s41409-022-01723-5

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