Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Natural and assisted conceptions in male cancer recipients of hematopoietic cell transplantation who stored their semen for fertility preservation

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Data availability

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy restrictions.


  1. De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, et al. EUROCARE-5 Working Group. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE–5-a population-based study. Lancet Oncol. 2014;15:23–34.

    Article  PubMed  Google Scholar 

  2. Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol. 2018;36:1994–2001.

    Article  PubMed  Google Scholar 

  3. Diesch-Furlanetto T, Rovó A, Galimard JE, Szinnai G, Dalissier A, Sedlacek P, et al. Pregnancy and pregnancy outcomes after hematopoietic stem cell transplantation in childhood: a cross-sectional survey of the EBMT Pediatric Diseases Working Party. Hum Reprod. 2021;36:2871–82.

    CAS  Article  PubMed  Google Scholar 

  4. Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, et al. Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the bone marrow transplant survivor study. Bone Marrow Transpl. 2006;37:1023–9.

    CAS  Article  Google Scholar 

  5. Dyer G, Gilroy N, Bradford J, Brice L, Kabir M, Greenwood M, et al. A survey of fertility and sexual health following allogeneic haematopoietic stem cell transplantation in New South Wales, Australia. Br J Haematol. 2016;172:592–601.

    Article  PubMed  Google Scholar 

  6. Ferrari S, Paffoni A, Reschini M, Noli S, Dallagiovanna C, Guarneri C, et al. Variables affecting long-term usage rate of sperm samples cryopreserved for fertility preservation in cancer patients. Andrology. 2021;9:204–11.

    CAS  Article  PubMed  Google Scholar 

  7. Reschini M, Somigliana E, Meazza C, Podda M, Guarneri C, Giacchetta D, et al. Sperm cryopreservation in adolescents with cancer. Eur J Obstet Gynecol Reprod Biol. 2021 260:198–202.

    Article  PubMed  Google Scholar 

  8. World Health Organisation (WHO). Laboratory manual for the examination and processing of human semen. Cambridge: Cambridge University Press; 2010.

    Google Scholar 

  9. Benaglia L, Busnelli A, Biancardi R, Vegetti W, Reschini M, Vercellini P, et al. Oocyte retrieval difficulties in women with ovarian endometriomas. Reprod Biomed Online. 2018;37:77–84.

    Article  PubMed  Google Scholar 

  10. Smith ADAC, Tilling K, Nelson SM, Lawlor DA. Live-birth rate associated with repeat in vitro fertilization treatment cycles. JAMA. 2015;314:2654–62.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). ART in Europe, 2017: results generated from European registries by ESHRE. Hum Reprod Open. 2021;2021:hoab026

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations



The authors’ roles are the following: MR and PV conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. MC, SF, and FGR collected data and reviewed and revised the manuscript. MR and ES coordinated and supervised data collection, and carried out statistical analysis. LB, FO, LB and FF prepared the first draft of the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Marco Reschini.

Ethics declarations

Competing interests

ES reports grants from Ferring, grants and personal fees from Merck-Serono, grants and personal fees from Theramex and Gedeon-Richter, outside the submitted work. MR reports personal fee from Merck-Serono outside the submitted work. PV reports grants from Theramex and ESHRE, speak honoraria from Merck. All the other authors do not have any competing interest to declare.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Reschini, M., Cristina, M., Ferrari, S. et al. Natural and assisted conceptions in male cancer recipients of hematopoietic cell transplantation who stored their semen for fertility preservation. Bone Marrow Transplant (2022).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI:


Quick links