This is a preview of subscription content
Access options
Subscribe to Journal
Get full journal access for 1 year
111,22 €
only 9,27 € per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.

Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
References
Schultz KR, Miklos DB, Fowler D, Cooke K, Shizuru J, Zorn E, et al. Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. Biol Blood Marrow Transpl. 2006;12:126–37.
Baird K, Steinberg SM, Grkovic L, Pulanic D, Cowen EW, Mitchell SA, et al. National Institutes of Health chronic graft-versus-host disease staging in severely affected patients: organ and global scoring correlate with established indicators of disease severity and prognosis. Biol Blood Marrow Transpl. 2013;19:632–9.
Aisa Y, Mori T, Nakazato T, Shimizu T, Yamazaki R, Ikeda Y, et al. Blood eosinophilia as a marker of favorable outcome after allogeneic stem cell transplantation. Transpl Int. 2007;20:761–70.
Kim DH, Popradi G, Xu W, Gupta V, Kuruvilla J, Wright J, et al. Peripheral blood eosinophilia has a favorable prognostic impact on transplant outcomes after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transpl. 2009;15:471–82.
Lingblom C, Andersson J, Andersson K, Wenneras C. Regulatory Eosinophils Suppress T Cells Partly through Galectin-10. J Immunol. 2017;198:4672–81.
Andersson J, Cromvik J, Ingelsten M, Lingblom C, Andersson K, Johansson JE, et al. Eosinophils from hematopoietic stem cell recipients suppress allogeneic T cell proliferation. Biol Blood Marrow Transpl. 2014;20:1891–8.
Ohkawara Y, Tamura G, Iwasaki T, Tanaka A, Kikuchi T, Shirato K. Activation and transforming growth factor-beta production in eosinophils by hyaluronan. Am J Respir Cell Mol Biol. 2000;23:444–51.
Rand TH, Silberstein DS, Kornfeld H, Weller PF. Human eosinophils express functional interleukin 2 receptors. J Clin Investig. 1991;88:825–32.
Onyema OO, Guo Y, Mahgoub B, Wang Q, Manafi A, Mei Z, et al. Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction. JCI Insight. 2019;4:e128241.
Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol. 2008;9:1253–60.
Schultz KR, Kariminia A, Ng B, Abdossamadi S, Lauener M, Nemecek ER, et al. Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies. Blood. 2020;135:1287–98.
Huenecke S, Cappel C, Esser R, Pfirrmann V, Salzmann-Manrique E, Betz S, et al. Development of Three Different NK Cell Subpopulations during Immune Reconstitution after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: Prognostic Markers in GvHD and Viral Infections. Front Immunol. 2017;8:109.
Acknowledgements
The Cancer and Allergy Foundation (2020-10154), the Swedish Cancer Society (21-1598 Pj), the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-966039), the IngaBritt and Arne Lundberg Research Foundation (2016-0041).
Author information
Authors and Affiliations
Contributions
CL did the multivariate models, interpreted results and participated in paper writing. KA did the experimental work and compiled the results. J-EJ recruited all study patients. CW was chiefly responsible for the study and writing of the paper.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
About this article
Cite this article
Lingblom, C., Andersson, K., Johansson, JE. et al. Multivariate modeling of eosinophil markers and other cellular immune parameters associated with the development of chronic graft-versus-host disease. Bone Marrow Transplant 57, 1335–1337 (2022). https://doi.org/10.1038/s41409-022-01708-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41409-022-01708-4