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Multivariate modeling of eosinophil markers and other cellular immune parameters associated with the development of chronic graft-versus-host disease

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Fig. 1: Multivariate models based on blood parameters measured post-stem cell transplantation.

Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

References

  1. Schultz KR, Miklos DB, Fowler D, Cooke K, Shizuru J, Zorn E, et al. Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. Biol Blood Marrow Transpl. 2006;12:126–37.

    Article  Google Scholar 

  2. Baird K, Steinberg SM, Grkovic L, Pulanic D, Cowen EW, Mitchell SA, et al. National Institutes of Health chronic graft-versus-host disease staging in severely affected patients: organ and global scoring correlate with established indicators of disease severity and prognosis. Biol Blood Marrow Transpl. 2013;19:632–9.

    Article  Google Scholar 

  3. Aisa Y, Mori T, Nakazato T, Shimizu T, Yamazaki R, Ikeda Y, et al. Blood eosinophilia as a marker of favorable outcome after allogeneic stem cell transplantation. Transpl Int. 2007;20:761–70.

    CAS  Article  Google Scholar 

  4. Kim DH, Popradi G, Xu W, Gupta V, Kuruvilla J, Wright J, et al. Peripheral blood eosinophilia has a favorable prognostic impact on transplant outcomes after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transpl. 2009;15:471–82.

    CAS  Article  Google Scholar 

  5. Lingblom C, Andersson J, Andersson K, Wenneras C. Regulatory Eosinophils Suppress T Cells Partly through Galectin-10. J Immunol. 2017;198:4672–81.

    CAS  Article  Google Scholar 

  6. Andersson J, Cromvik J, Ingelsten M, Lingblom C, Andersson K, Johansson JE, et al. Eosinophils from hematopoietic stem cell recipients suppress allogeneic T cell proliferation. Biol Blood Marrow Transpl. 2014;20:1891–8.

    CAS  Article  Google Scholar 

  7. Ohkawara Y, Tamura G, Iwasaki T, Tanaka A, Kikuchi T, Shirato K. Activation and transforming growth factor-beta production in eosinophils by hyaluronan. Am J Respir Cell Mol Biol. 2000;23:444–51.

    CAS  Article  Google Scholar 

  8. Rand TH, Silberstein DS, Kornfeld H, Weller PF. Human eosinophils express functional interleukin 2 receptors. J Clin Investig. 1991;88:825–32.

    CAS  Article  Google Scholar 

  9. Onyema OO, Guo Y, Mahgoub B, Wang Q, Manafi A, Mei Z, et al. Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction. JCI Insight. 2019;4:e128241.

    Article  Google Scholar 

  10. Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol. 2008;9:1253–60.

    CAS  Article  Google Scholar 

  11. Schultz KR, Kariminia A, Ng B, Abdossamadi S, Lauener M, Nemecek ER, et al. Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies. Blood. 2020;135:1287–98.

    Article  Google Scholar 

  12. Huenecke S, Cappel C, Esser R, Pfirrmann V, Salzmann-Manrique E, Betz S, et al. Development of Three Different NK Cell Subpopulations during Immune Reconstitution after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: Prognostic Markers in GvHD and Viral Infections. Front Immunol. 2017;8:109.

    Article  Google Scholar 

Download references

Acknowledgements

The Cancer and Allergy Foundation (2020-10154), the Swedish Cancer Society (21-1598 Pj), the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-966039), the IngaBritt and Arne Lundberg Research Foundation (2016-0041).

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CL did the multivariate models, interpreted results and participated in paper writing. KA did the experimental work and compiled the results. J-EJ recruited all study patients. CW was chiefly responsible for the study and writing of the paper.

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Correspondence to Christine Wennerås.

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Lingblom, C., Andersson, K., Johansson, JE. et al. Multivariate modeling of eosinophil markers and other cellular immune parameters associated with the development of chronic graft-versus-host disease. Bone Marrow Transplant 57, 1335–1337 (2022). https://doi.org/10.1038/s41409-022-01708-4

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