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A distinct signaling pathway in parvalbumin-positive interneurons controls flexible memory updating

Neuropsychopharmacology volume 47, pages 1283–1284 (2022)Cite this article

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Creating stable memories is critical for survival, as a means to find scarce resources (e.g., food/water) and avoid dangerous situations. However, the dynamic nature of an environment also requires that memories be updated with new information in order to respond to changing reward and threat contingencies. Thus, optimal brain circuits require both stability and flexibility to efficiently create memories and to update them according to ongoing changes in the environment [1]. The vast majority of research on memory processes has focused on forming stable memories that drive behavior, while much less is known about how these memories are updated when new information is provided.

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References

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Acknowledgements

We thank William Mau and Lauren Vetere for comments on an earlier version of this manuscript

Author contributions

DJC and TS contributed to conceiving, writing and editing the manuscript.

Funding

This work was supported by the McKnight Memory and Cognitive Disorders Award, the One Mind Otsuka Rising Star Award, the Irma T. Hirschl/Monique Weill-Caulier Research Award, NIMH DP2 MH122399 and NIMH R01 MH120162 to DJC; R01 NS116357 to TS.

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  1. Neuroscience Department, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1639, New York, NY, 10029, USA

    Denise J. Cai & Tristan Shuman

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  1. Denise J. Cai
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  2. Tristan Shuman
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Correspondence to Denise J. Cai.

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Cai, D.J., Shuman, T. A distinct signaling pathway in parvalbumin-positive interneurons controls flexible memory updating. Neuropsychopharmacol. 47, 1283–1284 (2022). https://doi.org/10.1038/s41386-022-01298-1

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  • DOI: https://doi.org/10.1038/s41386-022-01298-1

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