A new study shows that the prebiotic inulin improves vascular function in an animal model of cardiovascular disease. A key mechanism for how dietary gut microbiota modulation regulates host physiology through the activities of host–microbiota co-metabolic signalling via bile acids and glucagon-like peptide 1 is also explained.
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F.F. and K.M.T. conduct research projects funded by prebiotics companies (including Cargill, OlioCru and Solactis) and K.M.T. has accepted honoraria for speaking at international conferences from Abbott and Beneo-Orafti. K.M.T. is also coordinator of the project “CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health” (CABALA_Diet&Health), funded under the ERA-NET Cofund of the Joint Programming Initiative 'A healthy diet for a healthy life' part of the European Union's H2020 Research and Innovation Programme under grant agreement n.696300.
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Fava, F., Tuohy, K. Inulin regulates endothelial function: a prebiotic smoking gun?. Nat Rev Gastroenterol Hepatol 14, 392–394 (2017). https://doi.org/10.1038/nrgastro.2017.68