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Symptom perception in patients with NERD: do nerves matter?

Various mechanisms eliciting symptoms in GERD and its most common phenotypic presentation, nonerosive reflux disease (NERD), have been suspected and investigated. One study now suggests that superficial nerves in the oesophageal epithelium might have a key role in the pathogenesis of NERD and could represent a potential target for topical therapies.

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Correspondence to Edoardo Savarino.

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Savarino, E., Coletta, M. Symptom perception in patients with NERD: do nerves matter?. Nat Rev Gastroenterol Hepatol 14, 634–636 (2017).

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