Symptom-based diagnostic criteria have been criticized for being overly complex and performing modestly in differentiating organic from functional gastrointestinal diseases. The new Rome IV criteria now supersede Rome III. In general, these minor amendments are unlikely to lead to substantial improvement in accuracy and use in routine clinical care. Is a different approach required in future?
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Manning, A. P. et al. Towards positive diagnosis of the irritable bowel. Br. Med. J. 2, 653–654 (1978).
Drossman, D. A. et al. Identification of sub-groups of functional gastrointestinal disorders. Gastroenterol. Int. 3, 159–172 (1990).
Mearin, F. et al. Bowel disorders. Gastroenterology 150, 1393–1407 (2016).
Stanghellini, V. et al. Gastroduodenal disorders. Gastroenterology 150, 1380–1392 (2016).
Ford, A. C. et al. Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care. Gastroenterology 145, 1262–1270.e1 (2013).
Ford, A. C. et al. The Rome III criteria for the diagnosis of functional dyspepsia in secondary care are not superior to previous definitions. Gastroenterology 146, 932–935 (2014).
Ford, A. C. et al. Characteristics of functional bowel disorder patients: a cross-sectional survey using the Rome III criteria. Aliment. Pharmacol. Ther. 39, 312–321 (2014).
Fang, Y. -J. et al. Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria. Gut 64, 1517–1528 (2015).
Palsson, O. S. et al. Rome IV diagnostic questionnaires and tables for investigators and clinicians. Gastroenterology http://dx.doi.org/10.1053/j.gastro.2016.02.014 (2016).
Sood, R. et al. Systematic review with meta-analysis: the accuracy of diagnosing irritable bowel syndrome with symptoms, biomarkers and/or psychological markers. Aliment. Pharmacol. Ther. 42, 491–503 (2015).
The authors declare no competing financial interests.
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Sood, R., Ford, A. Rome IV criteria for FGIDs — an improvement or more of the same?. Nat Rev Gastroenterol Hepatol 13, 501–502 (2016). https://doi.org/10.1038/nrgastro.2016.110
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