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A challenge to our view of reflux oesophagitis pathogenesis

Since the recognition of reflux oesophagitis as a disease entity, scientists and clinicians have commonly assumed that the first step in its pathogenesis was a loss of superficial epithelial cells, brought about by caustic acid injury. However, new data suggests that it is time to reconsider this concept.

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Figure 1: Macroscopic and microscopic changes during gastroesophageal reflux.


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Correspondence to André J. P. M. Smout.

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Smout, A., Bredenoord, A. A challenge to our view of reflux oesophagitis pathogenesis. Nat Rev Gastroenterol Hepatol 13, 504–505 (2016).

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