Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Is 'ICC-opathy' present in gastroparesis-like syndrome?

The impact of chronic nausea and vomiting on quality of life and economic burden are substantial. New findings show that interstitial cells of Cajal are depleted or have ultrastructural changes in patients with chronic nausea and vomiting who have normal gastric emptying. Abnormalities of the gastric slow waves were also observed.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Hasler, W. L. & Chey, W. D. Nausea and vomiting. Gastroenterology 125, 1860–1867 (2003).

    Article  Google Scholar 

  2. Angeli, T. R. et al. Loss of interstitial cells of Cajal and patterns of gastric dysrhythmia in patients with chronic unexplained nausea and vomiting. Gastroenterology

  3. Parkman, H. P. & McCallum, R. W. Gastroparesis: pathophysiology, presentation, and treatment (Humana Press, 2012).

    Book  Google Scholar 

  4. Abell, T. L. et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine. Am. J. Gastroenterol. 103, 753–763 (2008).

    Article  Google Scholar 

  5. Quigley, E. M., Hasler, W. L. & Parkman, H. P. AGA technical review on nausea and vomiting. Gastroenterology 120, 263–286 (2001).

    CAS  Article  Google Scholar 

  6. Huizinga, J. D. & Chen, J. H. Interstitial cells of Cajal: update on basic and clinical science. Curr. Gastroenterol. Rep. 16, 363 (2014).

    Article  Google Scholar 

  7. Chen, J. & McCallum, R. W. Gastric slow wave abnormalities in patients with gastroparesis. Am. J. Gastroenterol. 87, 477–482 (1992).

    CAS  PubMed  Google Scholar 

  8. O'Grady, G. et al. Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping. Gastroenterology 143, 589–598. e1–e3 (2012).

    Article  Google Scholar 

  9. Reddymasu, S. C., Lin, Z., Sarosiek, I., Forster, J. & McCallum, R. W. Efficacy of gastric electrical stimulation in improving functional vomiting in patients with normal gastric emptying. Dig. Dis. Sci. 55, 983–987 (2010).

    Article  Google Scholar 

  10. Sachdeva, P. et al. Gastric emptying of solids and liquids for evaluation for gastroparesis. Dig. Dis. Sci. 56, 1138–1146 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Richard W. McCallum.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bashashati, M., McCallum, R. Is 'ICC-opathy' present in gastroparesis-like syndrome?. Nat Rev Gastroenterol Hepatol 12, 375–376 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing