Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Functional dyspepsia

Effects of antidepressants on functional dyspepsia

The effects of antidepressant therapy on functional dyspepsia were assessed in a double-blind, randomized controlled trial. Adequate response relief was reported by 40%, 53% and 38% of those given placebo, amitriptyline and escitalopram, respectively. Patients with ulcer-like functional dyspepsia were threefold more likely to report response relief with amitriptyline than placebo. Neither drug affected gastric emptying or meal-induced satiety, but both improved overall quality of life.


  1. Talley, N. J. et al. Effect of amitriptyline and escitalopram on functional dyspepsia: a multi-center, randomized, controlled study. Gastroenterology 10.1053/j.gastro.2015.04.020

Download references

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Effects of antidepressants on functional dyspepsia. Nat Rev Gastroenterol Hepatol 12, 313 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing