The effects of antidepressant therapy on functional dyspepsia were assessed in a double-blind, randomized controlled trial. Adequate response relief was reported by 40%, 53% and 38% of those given placebo, amitriptyline and escitalopram, respectively. Patients with ulcer-like functional dyspepsia were threefold more likely to report response relief with amitriptyline than placebo. Neither drug affected gastric emptying or meal-induced satiety, but both improved overall quality of life.
Talley, N. J. et al. Effect of amitriptyline and escitalopram on functional dyspepsia: a multi-center, randomized, controlled study. Gastroenterology 10.1053/j.gastro.2015.04.020
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Effects of antidepressants on functional dyspepsia. Nat Rev Gastroenterol Hepatol 12, 313 (2015). https://doi.org/10.1038/nrgastro.2015.85