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Multiple cilia suppress tumour formation

Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation.

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Figure 1: Notch1 activation suppresses multiciliate differentiation in choroid plexus epithelium.

References

  1. 1

    Guemez-Gamboa, A., Coufal, N. G. & Gleeson, J. G. Neuron 82, 511–521 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Madhivanan, K. & Aguilar, R. C. Traffic 15, 1031–1056 (2014).

    CAS  Article  Google Scholar 

  3. 3

    Corbit, K. C. et al. Nature 437, 1018–1021 (2005).

    CAS  Article  Google Scholar 

  4. 4

    Han, Y. G. et al. Nat. Neurosci. 11, 277–284 (2008).

    CAS  Article  Google Scholar 

  5. 5

    Li, L. et al. Nat. Cell Biol. 18, 418–430 (2016).

    CAS  Article  Google Scholar 

  6. 6

    Lun, M. P., Monuki, E. S. & Lehtinen, M. K. Nat. Rev. Neurosci. 16, 445–457 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Dang, L. et al. Oncogene 25, 487–491 (2006).

    CAS  Article  Google Scholar 

  8. 8

    Pierfelice, T. J. et al. Cancer Res. 71, 1115–1125 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Ezratty, E. J. et al. Cell 145, 1129–1141 (2011).

    CAS  Article  Google Scholar 

  10. 10

    Tsao, P. N. et al. Development 136, 2297–2307 (2009).

    CAS  Article  Google Scholar 

  11. 11

    Konishi, S. et al. Stem Cell Rep. 6, 18–25 (2016).

    CAS  Article  Google Scholar 

  12. 12

    Lafkas, D. et al. Nature 528, 127–131 (2015).

    CAS  Article  Google Scholar 

  13. 13

    Stasiulewicz, M. et al. Development 142, 2291–2303 (2015).

    CAS  Article  Google Scholar 

  14. 14

    Kong, J. H. et al. Dev. Cell 33, 373–387 (2015).

    CAS  Article  Google Scholar 

  15. 15

    Damkier, H. H., Brown, P. D. & Praetorius, J. Physiol. Rev. 93, 1847–1892 (2013).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Charles Eberhart.

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Eberhart, C. Multiple cilia suppress tumour formation. Nat Cell Biol 18, 368–369 (2016). https://doi.org/10.1038/ncb3331

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