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Actin puts the squeeze on Drosophila glue secretion

An Erratum to this article was published on 25 February 2016

This article has been updated

An actin filament coat promotes cargo expulsion from large exocytosing vesicles, but the mechanisms of coat formation and force generation have been poorly characterized. Elegant imaging studies of the Drosophila melanogaster salivary gland now reveal how actin and myosin are recruited, and show that myosin II forms a contractile 'cage' that facilitates exocytosis.

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Figure 1: Exocytosis of glue granules in the Drosophila salivary gland.

Change history

  • 04 February 2016

    In the version of this News and Views article originally published, the author's affiliation was incorrect. This was corrected online on 4 February 2016.


  1. 1

    Jahn, R. & Fasshauer, D. Nature 490, 201–207 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Burkhardt, P. J. Exp. Biol. 218, 506–514 (2015).

    Article  Google Scholar 

  3. 3

    Neuland, K. & Frick, M. Commun. Integr. Biol. 8, e1018496 (2015).

    Article  Google Scholar 

  4. 4

    Kozlov, M. M. & Chernomordik, L. V. Curr. Opin. Struct. Biol. 33, 61–67 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Miklavc, P. et al. J. Cell Sci. 125, 2765–2774 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Nightingale, T. D. et al. J. Cell Biol. 194, 613–629 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Segawa, A. & Yamashina, S. Cell Struct. Funct. 14, 531–544 (1989).

    CAS  Article  Google Scholar 

  8. 8

    Rousso, T., Schejter, E. D. & Shilo, B.-Z. Nat. Cell Biol. 18, 181–190 (2016).

    CAS  Article  Google Scholar 

  9. 9

    Tran, D. T., Masedunskas, A., Weigert, R. & Ten Hagen, K. G. Nat. Commun. 6, 10098 (2015).

    Article  Google Scholar 

  10. 10

    Fraenkel, G. & Brookes, V. J. Biol. Bull. 105, 442–449 (1953).

    Article  Google Scholar 

  11. 11

    Biyasheva, A., Do, T. V., Lu, Y., Vaskova, M. & Andres, A. J. Dev. Biol. 231, 234–251 (2001).

    CAS  Article  Google Scholar 

  12. 12

    Orci, L., Gabbay, K. H. & Malaisse, W. J. Science 175, 1128–1130 (1972).

    CAS  Article  Google Scholar 

  13. 13

    Farkas, R. et al. Nucleus 2, 489–499 (2011).

    Article  Google Scholar 

  14. 14

    Sundborger, A. C. & Hinshaw, J. E. F1000Prime Rep. 6, 85 (2014).

    Article  Google Scholar 

  15. 15

    Anantharam, A. et al. Mol. Biol. Cell 22, 1907–1918 (2011).

    CAS  Article  Google Scholar 

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Correspondence to Christien J. Merrifield.

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Merrifield, C. Actin puts the squeeze on Drosophila glue secretion. Nat Cell Biol 18, 142–144 (2016).

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