Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Actin puts the squeeze on Drosophila glue secretion

An Erratum to this article was published on 25 February 2016

This article has been updated

An actin filament coat promotes cargo expulsion from large exocytosing vesicles, but the mechanisms of coat formation and force generation have been poorly characterized. Elegant imaging studies of the Drosophila melanogaster salivary gland now reveal how actin and myosin are recruited, and show that myosin II forms a contractile 'cage' that facilitates exocytosis.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Exocytosis of glue granules in the Drosophila salivary gland.

Change history

  • 04 February 2016

    In the version of this News and Views article originally published, the author's affiliation was incorrect. This was corrected online on 4 February 2016.

References

  1. 1

    Jahn, R. & Fasshauer, D. Nature 490, 201–207 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Burkhardt, P. J. Exp. Biol. 218, 506–514 (2015).

    Article  Google Scholar 

  3. 3

    Neuland, K. & Frick, M. Commun. Integr. Biol. 8, e1018496 (2015).

    Article  Google Scholar 

  4. 4

    Kozlov, M. M. & Chernomordik, L. V. Curr. Opin. Struct. Biol. 33, 61–67 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Miklavc, P. et al. J. Cell Sci. 125, 2765–2774 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Nightingale, T. D. et al. J. Cell Biol. 194, 613–629 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Segawa, A. & Yamashina, S. Cell Struct. Funct. 14, 531–544 (1989).

    CAS  Article  Google Scholar 

  8. 8

    Rousso, T., Schejter, E. D. & Shilo, B.-Z. Nat. Cell Biol. 18, 181–190 (2016).

    CAS  Article  Google Scholar 

  9. 9

    Tran, D. T., Masedunskas, A., Weigert, R. & Ten Hagen, K. G. Nat. Commun. 6, 10098 (2015).

    Article  Google Scholar 

  10. 10

    Fraenkel, G. & Brookes, V. J. Biol. Bull. 105, 442–449 (1953).

    Article  Google Scholar 

  11. 11

    Biyasheva, A., Do, T. V., Lu, Y., Vaskova, M. & Andres, A. J. Dev. Biol. 231, 234–251 (2001).

    CAS  Article  Google Scholar 

  12. 12

    Orci, L., Gabbay, K. H. & Malaisse, W. J. Science 175, 1128–1130 (1972).

    CAS  Article  Google Scholar 

  13. 13

    Farkas, R. et al. Nucleus 2, 489–499 (2011).

    Article  Google Scholar 

  14. 14

    Sundborger, A. C. & Hinshaw, J. E. F1000Prime Rep. 6, 85 (2014).

    Article  Google Scholar 

  15. 15

    Anantharam, A. et al. Mol. Biol. Cell 22, 1907–1918 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Christien J. Merrifield.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Merrifield, C. Actin puts the squeeze on Drosophila glue secretion. Nat Cell Biol 18, 142–144 (2016). https://doi.org/10.1038/ncb3305

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3305

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing