Metabolic diversity drives cancer cell invasion

Baksh, Sanjeethan C.; Finley, Lydia W. S.

doi:10.1038/d41586-022-01301-1

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18 May 2022

Metabolic diversity drives cancer cell invasion

The migration and growth of cancer cells at sites far from the initial tumour is usually fatal. Metabolic heterogeneity — variable expression of an enzyme in the initial tumour — is identified as an early step in this deadly process.

Sanjeethan C. Baksh ⁰ &
Lydia W. S. Finley ¹

Sanjeethan C. Baksh
1. Sanjeethan C. Baksh is in the Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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Lydia W. S. Finley
1. Lydia W. S. Finley is in the Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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Cancer becomes life-threatening when cells in the initial (primary) tumour spread and grow in distant organs, a process termed metastasis. Metastasis is inefficient — only a subset of cells in a primary tumour can invade the bloodstream, survive in the hostile foreign environments of the circulatory system and distant organs, and manage to resume growth in alien tissues. How cells acquire this metastatic potential, and why only a small portion undergo metastasis, remain largely unknown¹.

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Nature 605, 627-628 (2022)

doi: https://doi.org/10.1038/d41586-022-01301-1

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